ChemicalBook > CAS DataBase List > PD 0332991 HCl

PD 0332991 HCl

Product Name
PD 0332991 HCl
CAS No.
827022-32-2
Chemical Name
PD 0332991 HCl
Synonyms
CS-365;PD 0332991 HCl;Palbociclib HCl;Palbociclib-025;Palbociclib-019-HCl;PD 0332991;PD-0332991;PD 0332991 hydrochloride;PD-0332991 (Palbociclib);PD 0332991 HCl USP/EP/BP;Palbociclib (hydrochloride)
CBNumber
CB22593007
Molecular Formula
C24H30ClN7O2
Formula Weight
484
MOL File
827022-32-2.mol
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PD 0332991 HCl Property

storage temp. 
= -70C
solubility 
≥14.48 mg/mL in H2O; ≥2.42 mg/mL in DMSO; ≥2.79 mg/mL in EtOH with gentle warming and ultrasonic
form 
Yellow liquid
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Safety

HS Code 
29399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.30487
Product name
StemSelect PD 0332991 - CAS 827022-32-2 - Calbiochem
Packaging
5mg
Price
$142
Updated
2024/03/01
Cayman Chemical
Product number
16273
Product name
PD 0332991 (hydrochloride)
Purity
≥95%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
16273
Product name
PD 0332991 (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$108
Updated
2024/03/01
Cayman Chemical
Product number
16273
Product name
PD 0332991 (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$195
Updated
2024/03/01
Cayman Chemical
Product number
16273
Product name
PD 0332991 (hydrochloride)
Purity
≥95%
Packaging
25mg
Price
$353
Updated
2024/03/01
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PD 0332991 HCl Chemical Properties,Usage,Production

Description

PD 0332991 is an orally active, selective inhibitor of the cyclin D kinases Cdk4 (IC50 = 11 nM) and Cdk6 (IC50= 16 nM) with no activity against a panel of 36 additional protein kinases. It has been reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma phosphorylation and inducing G1 arrest at nanomolar concentrations. PD 0332991 can inhibit the growth of certain ER-positive or HER2-amplified breast cancer cells (IC50s as low as 4 nM) and demonstrates synergy with tamoxifen and trastuzumab, respectively. PD 0332991 inhibition of Cdk4 activity has been used to demonstrate a role for insulin-activated cyclinD1-Cdk4 signaling in the control of glucose metabolism that is independent of cell cycle progression.

General Description

A cell-permeable, orally available and brain permeant, non-toxic pyridopyrimidinone compound that acts as a potent, selective, reversible, ATP competitive inhibitor of Cdk4 and Cdk6 (IC50 = 11, 9, and 15 nM for Cdk4/D1, Cdk4/D3 and Cdk6/D2, respectively). Hence, it reduces retinoblastoma protein phosphorylation at Ser780/Ser795 (IC50 = 66 nM in MDA-435 cells) and arrests cell cycle at G1 phase. Acts as a cytostatic agent, but does induce apoptotic cell death when used alone. However, it potentiates the cytotoxicity of dexamethasone (>Cat. No. 265005), bortezomib (>Cat. No. 504314), and tamoxifen (Cat. No. 579000) in estrogen receptor (ER)-positive cell lines. Exhibits only a trivial inhibitory activity towards Cdk2/E2, Cdk2/A, Cdk1/B and Cdk5/p25 in a 36-kinase panel (IC50 >10 μM). Improves endoderm differentiation of late G1-human embryonic stem cells expressing Smad2 or Smad3 (~ 750 nM) and further enhances endoderm differentiation into hepatic and pancreatic progenitor cells. Shown to regress the growth of human breast tumor xenografts in murine models (~150 mg/kg, p.o., daily).

Biochem/physiol Actions

Cell permeable: yes

target

CDK4/cyclin D1

References

[1] ivan diaz-padilla, lillian l. siu and ignacio duran. cyclin-dependent kinase inhibitors as potential targeted anticancer agents. invest new drugs. 2009, 27: 586–594.
[2] richard s finn, judy dering, dylan conklin, ondrej kalous, david j cohen, amrita j desai, charles ginther, mohammad atefi, isan chen, camilla fowst, gerret los and dennis j slamon. pd 0332991, a selective cyclin d kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. breast cancer research. 2009, 11: r77.

PD 0332991 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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PD 0332991 HCl Suppliers

China 177 India 4 United Kingdom 1 United States 25 Global 207
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
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United States
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AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
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United States
ProdList
2784
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Target molecule Corp.
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857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
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60
Musechem
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+1-800-259-7612
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+1-800-259-7612
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info@musechem.com
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United States
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4662
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InvivoChem
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+1-708-310-1919 +1-13798911105
Fax
708-557-7486
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sales@invivochem.cn
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United States
ProdList
6393
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Accela ChemBio Inc.
Tel
(+1)-858-699-3322
Fax
(+1)-858-876-1948
Email
info@accelachem.com
Country
United States
ProdList
19965
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58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
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58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
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United States
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19553
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Aladdin Scientific
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+1-833-552-7181
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sales@aladdinsci.com
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United States
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57511
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
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United States
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View Lastest Price from PD 0332991 HCl manufacturers

Henan Fengda Chemical Co., Ltd
Product
PD 0332991 HCl 827022-32-2
Price
US $31.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-25
Hebei Duling International Trade Co. LTD
Product
PD 0332991 HCl 827022-32-2
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1
Release date
2022-10-18
Dideu Industries Group Limited
Product
PD 0332991 HCl 827022-32-2
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-17

827022-32-2, PD 0332991 HClRelated Search:

PD0332991 Isethionate 6-acetyl-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde pyridine-3-sulfonyl chloride 4-[[(4-Fluorophenyl)imino]methyl]-phenol Flupirtine maleate 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one sacubitril 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)- Palbociclib 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one MK-2206 2HCl Ribociclib Trametinib (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol

  • PD 0332991 HCl
  • PALBOCICLIB HCL; PD0332991 HCL
  • 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride Palbociclib (PD-0332991) HCl
  • Palbociclib hydrochloride, >=98%
  • PD-0332991 (Palbociclib)
  • PD 0332991 hydrochloride
  • Palbociclib HCl
  • Palbociclib (hydrochloride)
  • Palbociclib (PD-0332991) HCl
  • 6-acetyl-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one hydrochloride
  • 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one Hydrochloride
  • PD 0332991 HCl (Palbociclib)
  • Palbociclib-025
  • PD 0332991 (Palbociclib) HCl
  • CS-365
  • Palbociclib-019-HCl
  • PD 0332991;PD-0332991
  • Pyrido[2,3-d]pyrimidin-7(8H)-one,6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-,monohydrochloride
  • Palbociclib (PD-0332991) hydrochloride
  • 6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one hydrochloride
  • 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-(piperazin-1-yl)pyridin-2-ylamino)pyrido[2,3-d]pyrimidin-
  • Palbociclib hydrochloride, 99%, a highly selective CDK4/6 inhibitor
  • PALBOCICLIB;PD-0332991 HYDROCHLORIDE;PD0332991 HYDROCHLORIDE;PD 0332991 HYDROCHLORIDE
  • Palbociclib, brand name: Ibrance
  • PD 0332991; PD-0332991; PD0332991; PD0332991; PD332991; PD-332991; PD 332991; PALBOCICLIB, BRAND NAME: IBRANCE
  • PD 0332991 HCl USP/EP/BP
  • Pyrido[2,3-d]pyrimidin-7(8H)-one,6-acetyl-8-cyclopentyl-5-me...
  • Palbociclib (monohydrochloride)
  • TIANFU-CHEM CAS:827022-32-2 PD 0332991 HCl
  • 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride1
  • Palbociclib Impurity 20 HCl
  • PALBOCICLIB (PD-0332991) (HCL SALT)
  • Palbociclib Impurity 22 HCl
  • 827022-32-2
  • C24H29N7O2HCl
  • C24H30ClN7O2
  • C24H29N7O2ClH
  • Inhibitors